
One thing I consistently did in hard to pick games involving the Colts during the regular season was side with Peyton Manning. He's simply the best quarterback to ever play the game, and it's really hard to pick against someone that knows the game so well.
That's why, once again, I'm siding with Manning and the Colts in a fairly high-scoring affair.
Final Score
Indianapolis Colts: 34
New Orleans Saints: 27
Most Valuable Player: Peyton Manning
Least Valuable Player: Hurricane Katrina (apparently not disastrous or recent enough to inspire the New Orleans to victory)